Standard Operating Procedure for Cleaning of Equipment Used for Lotions

1) Purpose

The purpose of this SOP is to outline the procedure for cleaning equipment used in the manufacturing of lotions to prevent cross-contamination, ensure product quality, and maintain regulatory compliance.

2) Scope

This SOP applies to all personnel involved in the cleaning and maintenance of equipment used for lotions within the pharmaceutical manufacturing facility.

3) Responsibilities

The responsibilities for executing this SOP are as follows:

Production Operators:

• Perform cleaning of equipment according to this SOP after each batch of lotion production.
• Ensure proper disassembly and reassembly of equipment components for cleaning.

Quality Control Personnel:

• Verify that equipment cleaning procedures are followed and documented.
• Conduct visual inspections to ensure cleanliness of equipment.

Quality Assurance Personnel:

• Review and approve cleaning procedures and records.
• Ensure compliance with regulatory requirements and internal standards.

4) Procedure

4.1 Pre-Cleaning Preparation:

• Ensure all necessary cleaning materials, detergents, and tools are available and approved for use.
• Verify that equipment is properly labeled with batch information and cleaning status.

4.2 Cleaning Process:

1. Disassembly:
   • Follow the equipment manufacturer’s instructions for proper disassembly of parts.
   • Separate components that come into contact with the lotion product.
2. Pre-Cleaning:
   • Remove visible residues and debris from equipment surfaces using dry cleaning methods (e.g., brushing, scraping).
3. Washing:
   • Prepare cleaning solutions as per approved procedures and