SOP Guide for Pharma

SOP for Dispensing Hazardous Materials

SOP for Dispensing Hazardous Materials

Standard Operating Procedure for Dispensing Hazardous Materials

1) Purpose

The purpose of this SOP is to establish safe and standardized procedures for dispensing hazardous materials to ensure the safety of personnel, prevent contamination, and minimize environmental risks.

2) Scope

This SOP applies to all personnel involved in dispensing hazardous materials in laboratories, storage areas, and production facilities. It includes solid, liquid, and gaseous hazardous substances.

3) Responsibilities

  • Operators: Follow proper dispensing protocols and use required Personal Protective Equipment (PPE).
  • Supervisors: Monitor dispensing operations and ensure compliance with safety guidelines.
  • Safety Officers: Conduct risk assessments, provide safety equipment, and oversee training.
  • Maintenance Team: Maintain dispensing equipment, ventilation systems, and spill kits.

4) Procedure

4.1 Preparation for Dispensing

  1. Material Identification:
    1. Review the Safety Data Sheet (SDS) of the material to identify:
      • Physical and chemical hazards
      • Permissible Exposure Limits (PEL)
      • Reactivity and compatibility
    2. Label all containers being used for dispensing clearly with:
      • Material name
      • Hazard classification
      • Precautionary warnings
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  3. Preparation of Dispensing Area:
    1. Conduct all dispensing operations in designated areas with proper ventilation (e.g., fume hoods or ventilated cabinets).
    2. Ensure spill kits and emergency eyewash stations are nearby and functional.
    3. Remove any ignition sources (open flames, sparks) when working with flammable materials.
  4. Personal Protective Equipment (PPE):
    1. Wear appropriate PPE based on the material’s hazard level:
      • Chemical-resistant gloves
      • Safety goggles or face
shields
  • Respirators for inhalation hazards
  • Lab coats or chemical-resistant aprons
  • Verify the PPE is intact, clean, and suitable for the material being dispensed.
  • Equipment Readiness:
    1. Inspect all dispensing equipment (e.g., pumps, funnels, drip trays) for leaks, cracks, or malfunctions.
    2. Use only tools and containers compatible with the hazardous material (e.g., non-reactive containers for acids).
    3. Ensure secondary containment trays are in place for liquids.
  • 4.2 Dispensing Procedure

    1. General Dispensing Guidelines:
      1. Always dispense hazardous materials slowly to prevent spills, splashes, or vapor release.
      2. Do not overfill containers; leave sufficient headspace to allow for material expansion.
      3. Use funnels and pumps to transfer liquids; avoid direct pouring whenever possible.
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    3. Dispensing Flammable Liquids:
      1. Dispense flammable liquids in designated areas free of ignition sources.
      2. Use grounded or bonded containers to prevent static electricity buildup.
      3. Ensure that containers are tightly sealed immediately after dispensing.
    4. Dispensing Corrosive Materials:
      1. Use chemical-resistant pumps or equipment for acids and bases.
      2. Handle corrosive materials under a fume hood to avoid vapor inhalation.
      3. Rinse external surfaces of containers after dispensing to prevent residual contamination.
    5. Dispensing Toxic Gases:
      1. Handle toxic gases only in properly ventilated gas cabinets or fume hoods.
      2. Use compatible regulators and leak detectors to ensure connections are airtight.
      3. Monitor gas levels using portable gas detection devices.
    6. Dispensing Powders and Granular Materials:
      1. Work under localized exhaust systems to prevent dust exposure.
      2. Use scoopers and tools made of non-reactive materials.
      3. Wear respirators to protect against inhalation of particulates.

    4.3 Post-Dispensing Activities

    1. Securing Materials:
      1. Ensure containers are sealed properly and labeled clearly before returning to storage.
      2. Store materials in designated areas, maintaining segregation for incompatible chemicals.
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    3. Decontamination:
      1. Clean all tools and dispensing equipment using appropriate neutralizing or cleaning agents.
      2. Dispose of PPE, wipes, or absorbents contaminated with hazardous materials as hazardous waste.
    4. Waste Management:
      1. Collect all waste material in designated hazardous waste containers.
      2. Label waste containers with the material name, hazard class, and date.
      3. Dispose of waste according to facility guidelines and regulatory requirements.

    4.4 Emergency Protocols

    1. Spill Management:
      1. Stop dispensing operations immediately and secure the area.
      2. Use spill kits to contain minor spills; report large spills to the Safety Officer immediately.
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    3. Exposure to Hazardous Material:
      1. Skin contact: Remove contaminated clothing and rinse the affected area with water for 15 minutes.
      2. Eye contact: Flush eyes using an eyewash station for at least 15 minutes.
      3. Inhalation: Move to fresh air and seek medical assistance if symptoms persist.
    4. Fire Emergency:
      1. Activate the fire alarm and evacuate the area immediately.
      2. Use Class B fire extinguishers for flammable liquids if trained to do so.
      3. Contact emergency services and provide details of the material involved.

    5) Abbreviations, if any

    • SDS: Safety Data Sheet
    • PPE: Personal Protective Equipment

    6) Documents, if any

    • Hazardous Material Dispensing Log
    • Incident Reports
    • Safety Data Sheets (SDS)

    7) Reference, if any

    • OSHA Hazard Communication Standard (29 CFR 1910.1200)
    • NFPA Guidelines for Safe Handling of Flammable and Hazardous Chemicals

    8) SOP Version

    Version: 1.0

    Annexure

    Template 1: Hazardous Material Dispensing Log

     
    Date Material Name Quantity Dispensed Handled By Remarks
    DD/MM/YYYY Material Name XX Liters/Grams Employee Name Process Completed
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