Standard Operating Procedure for Handling Nanoparticle Precursors

1) Purpose

This SOP outlines the procedures for the preparation and safe handling of nanoparticle precursors used in the production of nanoparticle formulations. The objective is to ensure proper preparation, safe handling, and prevention of contamination.

2) Scope

This SOP applies to all laboratory staff and operators who are responsible for the preparation and handling of nanoparticle precursors within the laboratory and production areas.

3) Responsibilities

• Operators: Responsible for handling and preparing nanoparticle precursors in compliance with this SOP.
• QA: Ensures quality of the prepared precursors and compliance with safety guidelines.

4) Procedure

4.1 Preparation of Nanoparticle Precursors

4.1.1 Required Materials

• 4.1.1.1 Gather all required precursor materials, such as polymers, surfactants, lipids, or metals, depending on the nanoparticle type.
• 4.1.1.2 Ensure all equipment and containers are cleaned and sanitized according to laboratory guidelines.

4.1.2 Weighing and Dispensing

• 4.1.2.1 Use a calibrated balance to weigh the exact amounts of precursors as per the formulation batch record.
• 4.1.2.2 Dispense the required materials into properly labeled containers for each batch.

4.2 Handling of Precursors

4.2.1 Safety Measures

• 4.2.1.1 Ensure all operators are wearing appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coats.
• 4.2.1.2 Work in a fume hood or well-ventilated area when handling volatile or