at the end of each shift.

Wipe down high-touch surfaces such as door handles and light switches with disinfectant.

Document activities in the Daily Cleaning Log (Annexure-1).

Weekly Cleaning:

• Clean storage racks, pallets, and shelving units using appropriate cleaning agents.
• Check for and remove any pest infestations or mold growth.
• Document weekly activities in the Weekly Cleaning Log (Annexure-2).

Monthly Deep Cleaning:

• Conduct deep cleaning of the entire storage area, including walls, ceilings, and ventilation systems.
• Use approved cleaning agents that are non-reactive with stored materials.
• Document deep cleaning activities in the Monthly Deep Cleaning Log (Annexure-3).

5.2 Cleaning Procedures

1. General Cleaning Protocol:
   • Wear Personal Protective Equipment (PPE) as required, including gloves, masks, and protective clothing.
   • Use designated cleaning equipment (e.g., mops, brooms, vacuums) for specific storage zones to prevent cross-contamination.
   • Ensure all cleaning agents are labeled and stored separately from raw materials.
2. Spill Management:
   • Immediately clean any spills using appropriate spill kits and notify the Warehouse Manager.
   • Document spills and corrective actions in the Spill Cleaning Log (Annexure-4).

5.3 Maintenance of Storage Areas

1. Routine Maintenance:
   • Inspect storage racks, shelving units, and pallets weekly for structural integrity.
   • Ensure temperature and humidity control systems are functioning correctly.
   • Document routine maintenance activities in the Maintenance Log (Annexure-5).
2. Repairs and Replacements:
   • Report damaged racks, flooring, or environmental control systems immediately to the Warehouse Manager.
   • Coordinate with maintenance teams to repair or replace faulty equipment.
   • Document all repairs and replacements in the Repair Log (Annexure-6).

5.4 Handling of Deviations

1. Deviation Detection:
   • Identify deviations such as unclean surfaces, pest infestations, or malfunctioning equipment during routine checks.
   • Isolate affected areas and materials to prevent contamination.
   • Document deviations in the Deviation Log (Annexure-7).
2. Corrective Actions:
   • Initiate immediate corrective actions, including re-cleaning, fumigation, or equipment repair.
   • Document corrective actions in the Corrective Action Log (Annexure-8).

5.5 Verification and Compliance Monitoring

1. QA Inspections:
   • QA will conduct monthly inspections to verify cleaning and maintenance activities.
   • Document inspection findings in the QA Inspection Log (Annexure-9).
2. Compliance Audits:
   • Conduct quarterly compliance audits to ensure adherence to GMP standards.
   • Document audit results in the Compliance Audit Log (Annexure-10).

6. Abbreviations

• SOP: Standard Operating Procedure
• GMP: Good Manufacturing Practice
• QA: Quality Assurance
• PPE: Personal Protective Equipment

7. Documents

1. Daily Cleaning Log (Annexure-1)
2. Weekly Cleaning Log (Annexure-2)
3. Monthly Deep Cleaning Log (Annexure-3)
4. Spill Cleaning Log (Annexure-4)
5. Maintenance Log (Annexure-5)
6. Repair Log (Annexure-6)
7. Deviation Log (Annexure-7)
8. Corrective Action Log (Annexure-8)
9. QA Inspection Log (Annexure-9)
10. Compliance Audit Log (Annexure-10)

8. References

• 21 CFR Part 211 – Current Good Manufacturing Practice for Finished Pharmaceuticals
• WHO GMP Guidelines
• OSHA Standards for Workplace Safety

9. SOP Version

Version: 2.0

10. Approval Section

	Prepared By	Checked By	Approved By
Signature
Date
Name
Designation
Department

11. Annexures

Annexure-1: Daily Cleaning Log

Date	Area Cleaned	Cleaning Method	Performed By
17/02/2025	General Storage Area	Sweeping and Dusting	Ravi Kumar

Annexure-2: Weekly Cleaning Log

Date	Area Cleaned	Cleaning Method	Performed By
17/02/2025	Storage Racks	Wiping with Disinfectant	Sunita Sharma

Annexure-3: Monthly Deep Cleaning Log

Date	Area Cleaned	Cleaning Method	Performed By
01/02/2025	Entire Warehouse	Deep Cleaning with Approved Agents	Anjali Mehta

Annexure-4: Spill Cleaning Log

Date	Spill Type	Area Affected	Action Taken	Performed By
15/02/2025	Chemical Spill	Hazardous Storage Area	Used Spill Kit and Ventilated Area	Ravi Kumar

Annexure-5: Maintenance Log

Date	Equipment/Area	Maintenance Activity	Performed By
16/02/2025	Temperature Control System	Filter Replacement	Anjali Mehta

Annexure-6: Repair Log

Date	Area Repaired	Issue	Repair Details	Performed By
14/02/2025	Storage Rack	Bent Support	Reinforced Rack Structure	Sunita Sharma

Annexure-7: Deviation Log

Date	Deviation	Corrective Action	Reported By
13/02/2025	Unclean Floor Detected	Re-cleaned Area	Ravi Kumar

Annexure-8: Corrective Action Log

Date	Issue	Corrective Action Taken	Performed By
12/02/2025	Pest Infestation	Fumigation	Ravi Kumar

Annexure-9: QA Inspection Log

Date	Area Inspected	Findings	Corrective Actions	Inspected By
10/02/2025	General Storage Area	No Issues Detected	N/A	Anjali Mehta

Annexure-10: Compliance Audit Log

Date	Audit Type	Findings	Corrective Actions	Audited By
01/02/2025	Storage Area Cleaning Audit	Compliant	N/A	Anjali Mehta

Revision History:

Revision Date	Revision No.	Revision Details	Reason for Revision	Approved By
01/01/2024	1.0	Initial Version	New SOP	QA Head
17/02/2025	2.0	Updated Cleaning and Maintenance Procedures	Regulatory Compliance	QA Head