explosion-proof cabinets that meet OSHA and NFPA standards for the storage of flammable liquids.

Ensure cabinets have self-closing doors, grounding connections, and ventilation options.

Installation Guidelines:

• Install cabinets in well-ventilated areas, away from ignition sources, and maintain clear access for emergency response.
• Document installation details in the Cabinet Installation Log (Annexure-1).

5.2 Storage of Flammable Raw Materials

1. Labeling and Segregation:
   • Clearly label all flammable materials with hazard symbols and store them in appropriate containers (e.g., safety cans).
   • Segregate incompatible substances, such as acids and bases, to prevent chemical reactions.
   • Document storage arrangements in the Flammable Material Storage Log (Annexure-2).
2. Capacity Limits:
   • Do not exceed the maximum storage capacity of the cabinet as specified by the manufacturer.
   • Document capacity checks in the Capacity Monitoring Log (Annexure-3).

5.3 Handling Procedures for Flammable Materials

1. Personal Protective Equipment (PPE):
   • Wear appropriate PPE, including flame-resistant gloves, goggles, and protective clothing, while handling flammable materials.
   • Document PPE checks in the PPE Usage Log (Annexure-4).
2. Safe Handling Practices:
   • Use bonding and grounding procedures to prevent static discharge during material transfer.
   • Handle materials in designated flammable liquid storage areas, away from open flames and heat sources.
   • Document handling activities in the Material Handling Log (Annexure-5).

5.4 Monitoring and Maintenance of Cabinets

1. Regular Inspections:
   • Inspect explosion-proof cabinets monthly for signs of damage, corrosion, or malfunction.
   • Ensure that the self-closing mechanisms and venting systems are functional.
   • Document inspection results in the Cabinet Inspection Log (Annexure-6).
2. Maintenance Schedule:
   • Perform routine maintenance, including lubrication of hinges and cleaning of vent filters, as per the manufacturer’s instructions.
   • Document maintenance activities in the Maintenance Log (Annexure-7).

5.5 Handling of Deviations and Spills

1. Deviation Detection:
   • Identify deviations in storage conditions or cabinet functionality through regular monitoring.
   • Isolate affected materials immediately and initiate corrective actions.
   • Document deviations in the Deviation Log (Annexure-8).
2. Spill Response:
   • In case of a spill, evacuate the area, use appropriate spill containment kits, and notify the emergency response team.
   • Ventilate the area and ensure safe disposal of contaminated materials according to hazardous waste protocols.
   • Document spill responses in the Spill Response Log (Annexure-9).

5.6 Periodic Review and Compliance Monitoring

1. Warehouse Inspections:
   • Conduct routine inspections to ensure compliance with storage and safety protocols.
   • Document inspection findings in the Warehouse Inspection Log (Annexure-10).
2. QA Compliance Audits:
   • QA will perform audits to verify compliance with safety and regulatory standards for flammable material storage.
   • Document audit findings in the Compliance Audit Log (Annexure-11).

6. Abbreviations

• SOP: Standard Operating Procedure
• GMP: Good Manufacturing Practice
• QA: Quality Assurance
• PPE: Personal Protective Equipment
• OSHA: Occupational Safety and Health Administration
• NFPA: National Fire Protection Association

7. Documents

1. Cabinet Installation Log (Annexure-1)
2. Flammable Material Storage Log (Annexure-2)
3. Capacity Monitoring Log (Annexure-3)
4. PPE Usage Log (Annexure-4)
5. Material Handling Log (Annexure-5)
6. Cabinet Inspection Log (Annexure-6)
7. Maintenance Log (Annexure-7)
8. Deviation Log (Annexure-8)
9. Spill Response Log (Annexure-9)
10. Warehouse Inspection Log (Annexure-10)
11. Compliance Audit Log (Annexure-11)

8. References

• 21 CFR Part 211 – Current Good Manufacturing Practice for Finished Pharmaceuticals
• OSHA 29 CFR 1910.106 – Flammable Liquids
• NFPA 30 – Flammable and Combustible Liquids Code
• WHO GMP Guidelines

9. SOP Version

Version: 2.0

10. Approval Section

	Prepared By	Checked By	Approved By
Signature
Date
Name
Designation
Department

11. Annexures

Annexure-1: Cabinet Installation Log

Date	Cabinet ID	Location	Installed By
13/02/2025	EXP-CAB-001	Flammable Storage Area 1	Ravi Kumar

Annexure-2: Flammable Material Storage Log

Date	Material Name	Batch Number	Cabinet ID	Stored By
13/02/2025	Toluene	TOL-2025-001	EXP-CAB-001	Sunita Sharma

Annexure-3: Capacity Monitoring Log

Date	Cabinet ID	Capacity Utilization (%)	Checked By
13/02/2025	EXP-CAB-001	75%	Ravi Kumar

Annexure-4: PPE Usage Log

Date	Material Handled	PPE Used	Issued By
13/02/2025	Toluene	Gloves, Goggles, Flame-Resistant Clothing	Anjali Mehta

Annexure-5: Material Handling Log

Date	Material Name	Batch Number	Handling Activity	Handled By
13/02/2025	Toluene	TOL-2025-001	Transferred to QC Lab	Sunita Sharma

Annexure-6: Cabinet Inspection Log

Date	Cabinet ID	Inspection Findings	Inspected By
13/02/2025	EXP-CAB-001	No issues detected	Anjali Mehta

Annexure-7: Maintenance Log

Date	Cabinet ID	Maintenance Activity	Performed By
12/02/2025	EXP-CAB-001	Lubricated hinges and checked seals	Ravi Kumar

Annexure-8: Deviation Log

Date	Deviation	Action Taken	Reported By
12/02/2025	Cabinet door not sealing properly	Repaired door mechanism	Ravi Kumar

Annexure-9: Spill Response Log

Date	Material Spilled	Spill Size	Action Taken	Handled By
12/02/2025	Toluene	250 ml	Used spill kit, ventilated area	Sunita Sharma

Annexure-10: Warehouse Inspection Log

Date	Area Inspected	Inspector	Findings	Corrective Actions
13/02/2025	Flammable Storage Area 1	Anjali Mehta	No deviations found	N/A

Annexure-11: Compliance Audit Log

Date	Audit Type	Findings	Corrective Actions	Audited By
14/02/2025	Explosion-Proof Cabinet Compliance Audit	Compliant	N/A	Anjali Mehta

Revision History:

Revision Date	Revision No.	Revision Details	Reason for Revision	Approved By
01/01/2024	1.0	Initial Version	New SOP	QA Head
13/02/2025	2.0	Updated Handling and Storage Procedures	Regulatory Compliance	QA Head